Michael Lueckheide | Faculty Profiles

Diplomas/Degrees

Ph. D. in Chemistry, University of Chicago (2018)

M.S. in Chemistry, University of Chicago (2014)

B.A. in Chemistry, Vassar College (2013)

B.A. in Physics, Vassar College (2013)

Recent Courses

Biochemistry II

Guided Research In Biology

Guided Research Peptide Polymer Conjugates For Dentistry

Guided Research In Chemistry

Physical Chemistry I

Physiological Chemistry Lecture

Research Seminars In Chemistry

Research Seminars In Chemistry I

Research Seminars In Chemistry I I

Research Seminars In Chemistry

Thesis Research Writing, And Presentation

Specialization/Interests

Biochemistry, Polymer Chemistry, and Physical Chemistry

Teaching Philosophy

In lecture, recitation, and laboratory, I want to engage students in group work to practice concepts from class, and to take part in laboratory activities. This style is most similar to my work as a teaching assistant at UChicago. Small group settings make it easier to solicit answers from students, and to occasionally have a student talk through their method of solving a problem.

At the end of a course, I want my students to be able to methodically apply the concepts they have learned in future chemistry courses and laboratories, and to analyze new information in the context of their scientific skills and practices. This will also prepare them for careers and any future science courses they take.

Research Interests

ORCiD: 0000-0001-8310-0557

I will endeavor to form collaborations both within and outside of the Chemistry department, to introduce techniques in peptide and polymer synthesis and characterization to our students, and to research those molecules in the context of their interactions with biopolymers.

Both my Ph. D. research (at UChicago) and my postdoctoral research (at NIST) heavily involved X-ray and neutron scattering techniques performed at government laboratories like Argonne National Laboratory, Oak Ridge National Laboratory, and the National Institute of Standards and Technology. I have previously applied these scattering techniques to biological and polymer materials, for purposes ranging from the development of drug delivery vehicles, to determining the behavior of proteins and nucleic acids interacting with polymers. Long Island hosts Brookhaven National Laboratory, and its National Synchrotron Light Source II and another major research goal of mine is to strengthen the connection of 依依社区’s students and faculty to this world-renowned research institution. Future projects will involve designing polymers that can self-assemble into vehicles that would encapsulate small molecules and nucleic acids to help treat trichomoniasis, and that would be characterized using X-ray scattering.

Chapters

P. D. Pickett, Y. Ma, N. D. Posey, M. Lueckheide, V. M. Prabhu, Structure and Phase Behavior of Polyampholytes and Polyzwitterions, Wiley-VCH Gmbh, 2022, DOI: 10.1002/9783527815562.mme0056

Articles

M. Lueckheide, A. Marin, H. D. Tagad, N. D. Posey, V. M. Prabhu, A. K. Andrianov, Monitoring Protein Complexation with Polyphosphazene Polyelectrolyte Using Automated Dynamic Light Scattering Titration and Asymmetric Flow Field Flow Fractionation and Protein Recognition Immunoassay, ACS Polymers Au, 2023,

W. Zhang, Y. Ma, N. D. Posey, M. J. Lueckheide, V. M. Prabhu, J. F. Douglas, Combined Simulation and Experimental Study of Polyampholyte Solution Properties: Effects of Charge Ratio, Hydrophobic Groups, and Polymer Concentration, Macromolecules, 55, 6750-6761, 2022

P. D. Pickett, Y. Ma, M. Lueckheide, Y. Mao, V. M. Prabhu, Temperature dependent single-chain structure of poly[3-(acrylamidopropyl-dimethylammonum) propyl-1-sulfonate] via small-angle neutron scattering, The Journal of Chemical Physics, 2022,

Z. Zhou, C. F. Yeh, M. Mellas, M. J. Oh, J. Zhu, J. Li, R. T. Huang, D. Harrison, T. P. Shentu, D. Wu, M. Lueckheide, L. Carver, E. J. Chung, L. Leon, K. C. Yang, M. V. Tirrell, Y. Fang, Targeted polyelectrolyte complex micelles treat vascular complications in vivo, Proceedings of the National Academy of Sciences, 118, 50, 1-12, 2021

N. D. Posey, Y. Ma, M. Lueckheide, J. Danischewski, J. A. Fagan, V. M. Prabhu, Tuning Charge Balance in Aliphatic Polycarbonates Alters Solubility and Protein Complexation Behavior, ACS Omega, 6, 22589-22602, 2021

M. Lueckheide†, J. R. Vieregg†, A. J. Bologna, L. Leon, M. V. Tirrell, Structure-property relationships of oligonucleotide polyelectrolyte complex micelles, Nano Letters, 18, 11, 7111-7117, 2018

J. R. Vieregg†, M. Lueckheide†, A. B. Marciel, L. Leon, A. J. Bologna, J. R. Rivera, M. V. Tirrell, Oligonucleotide-peptide complexes: phase control by hybridization, Journal of the American Chemical Society, 140, 5, 1632-1638, 2018.

Conference Presentations

Oral Presentation. M. Lueckheide, A. Marin, H. Tagad, N. Posey, V. Prabhu, A. K. Andrianov, “Investigating protein-polyphosphazene complexation with automated dynamic light scattering titrations, asymmetric flow field flow fractionation, and protein recognition immunoassay, American Chemical Society March Meeting, March 2024, New Orleans, Louisiana, March 17-21

Poster Presentation. M. Lueckheide, T. R. Blake, B. McCarthy, D. P. Walton, R. M. Waymouth, Y. Ma, Y. Mao, V. M. Prabhu, “Solution structure of amphiphilic charged transporters (ACTs) and ACT-polynucleotide complexes for delivering therapeutic nucleic acids," American Chemical Society March Meeting, March 2021, Virtual Conference

Poster Presentation. M. Lueckheide, T. Blake, D. Walton, R. M. Waymouth, Y. Ma, Y. Mao, V. M. Prabhu, "Solution Structure of Lipophilic-Charged Block Cooligomers and Complexes for Delivering Therapeutic Nucleic Acids," American Conference on Neutron Scattering, July 2020, Virtual Conference

Oral Presentation. M. Lueckheide, “Multimodal characterization of oligonucleotide-polyelectrolyte complex micelles,” 12th International Symposium on Polyelectrolytes, 2018, Wageningen, Netherlands, August 27-31

Oral Presentation. M. Lueckheide. “Oligonucleotide/block-copolymer micelles: shape, size, and structure,” National Graduate Research Polymer Conference, June 10-12, 2018, Minneapolis, MN

Poster Presentation. M. Lueckheide, J. Vieregg, A Marciel, S. Srivastava, A. Bologna, M. Tirrell, "Effects of Nucleic Acid Modifications on Micelle Stability and Structure," 91st American Chemical Society Colloid and Surface Science Symposium, July 2017, New York, NY

Poster Presentation. M. Lueckheide, J. Vieregg, A. Marciel, L. Leon, A. Bologna, J. Reyes, M. Tirrell, Gordon Research Conference on Bioinspired Materials, June 2016, Les Diablerets, Switzerland

Grants

Michael Lueckheide, Adelphi Faculty Development Grant, “Synthesis, and Characterization of Amino Acid Sequences for Targeting Trichomonas Vaginalis,” 依依社区, 2023

Theses Advised

Honors College Thesis Committee Member for Kendra Jimenez: "Novel Hypervalent Iodine Compounds Containing Three Carbon Ligands and Their Use for C(sp3)--C(sp3) Formation," December 2023

Honors College Thesis Committee Member for Hannah Sharifian: "Pediatric Bone Fractures, Depression, & Vitamin D Status During the COVID-19 Pandemic: A Review," May 2023